LISA is, as its subtitle suggests, is one of the more emotionally painful experiences I've had with a game, and I mean that as a positive. This game's story puts Brad through so much torment that it almost feels like it hates the player themself at times. I don't want to go into the story beats at all because they're best experienced completely blindly, but just know that despite how damn funny the humor in this game is, its revenge narrative and main character are heartwrenching at times. It's difficult to progress in this game at times because of how fucked the next steps that Brad is going to take are. If you're familiar with how dark Mother 3 can get, this game has that same sort of feeling, but can obviously go so much further with it because it's not a Nintendo game.
I wish I could sing nothing BUT praises for this game, but it is an RPGMaker game. I love turn-based combat games, but LISA doesn't do too much to make its combat exciting. The encounters aren't annoying, just could've been less repetitive after you figure out what status effects do and how to execute dial combos. Also, the customization in this game doesn't really do it for me, it's just completely whatever.
Navigating the world can be a puzzle sometimes and it's pretty fun, not revolutionary, but it's hard to be bored on your way to your next destination.
Overall though, great experience that I have to recommend to anyone that enjoys RPGs in the style of the Mother series or Undertale, as much as I'm sure that comparison is such a beaten dead horse that it's just a pile of guts by now.