Knot Me! is a 3D action-adventure game designed to explore sexual kinks, sexual culture, sexual consent, and other taboo topics. The player controls Regina, a possum-girl, and Señor Edgar, her talking bondage rope. Using Señor Edgar’s ability to tie knots, swing from overhead fixtures, and whip a short distance in front of her, Regina explores the four floors of Red Velvet while on a mission to interview the elusive Spider Queen of Bondage. On the way, she must satisfy three boss characters by appealing to their sexual kinks, culminating with the Spider Queen herself.