This game is an extremely well-made deconstruction of Sam and Max as a franchise. It constantly subverts and plays around with the two's relationship in extremely creative ways.
They managed to pull off a genuinely investable story in a series that usually refuses to ever drop the absurdity. It doesn't skim out on the humor either, it's still extremely funny.
Easily the best Sam and Max, and one of the best point and click games.