Basically just more of the same insane shit from the first game—except there's aren't nearly as many jokes about sexual misconduct. The Re-Up (whatever the fuck that means) instead reaches out to cover more nuanced topics, such as double suicide via drug overdose, watching your mom die from a heart attack and only being concerned with her estate, and introducing at least 3 insanely repressed toxic lesbians (that's what makes it fun tho). So y'know, funnier than the first game in basically every way.
Jecka was not included in the lesbian count, but that's because we already knew she was a repressed lesbian from the first game.