If you count Mr. Bright he technically blows up the moon twice.

Something something laser piss.

I only found out about this because I know that in the actual series the moon is blown up several times.

Luigi is a menace to society.

I've never played this one but the moon sure does go boom.

This is a case of you can destroy the moon, but it won't happen for every player.

You just shoot the moon right out of the sky how cool is that!?