Honestly this is one of the best remakes I think I've ever played ever. It's literally the PS2 game untouched with all of the old stuff except it feels better, with SEVERAL quality of life improvements to the gameplay to make it feel more fast paced and fair. For example: You can shoot your death ray straight down this time, draining lets you shoot and drain at the same time if that wasn't in the original, you can not only dodge but you can just do straight up hoverboarding, and there's more I can't account for. Now again I love the original but it's been years since I touched the original game on PS2, so if I'm wrong about anything then feel free to discard that. But at the same time it again keeps the original cast, keeps everything that made it special but it even added content cut from the original (mainly one mission called "The Mutant Menace"). And the amount more extra detail they put into each of the levels is astounding! The only things I could say that maybe could mess with people is the art style? That's subjective for me because I think the art style lends to the whole 50's parody aesthetic, though I think having everyone not look like warped cartoonish versions of themselves would've been ok too.

Also holy s h i t that final boss fight in the remake feels WAY harder than the one in the original. Other than that I don't know, I can't really say too much except I hope these guys remake the second and ESPECIALLY the third then continue on with the franchise from there.

Pros:
Pretty much everything is back but better
Updated environment
Added extra content

Cons:
It's subjective but some have been mixed on the art style? I don't get it
Still feels like the old ps2 game in some degrees

Overall fantastic 15 hour experience I say anyone who is fans of the original should DEFINITELY try out

From Steam Reviews: https://steamcommunity.com/id/gamemast15r/recommended/

As someone that played the original Destroy All Humans and its sequel to death on PS2 back in the day, honestly this is one of the best game remakes I've ever seen. As far as staying true to the original but improving it making smart changes, Destroy All Humans Remake is a slam dunk.

There's so many little changes they made to the remake to simplify things and make the game just smoother and more fun to play. It puts actions on single buttons that required multiple before. You can hover, aim and shoot, use PK abilities all at the same time and it just works so well. No more concentration meter. It takes mechanics from the sequel and retro fits them to the original. As far as added content, they added a bunch of new side missions which are quite fun if not spectacular.

At the end of the day it's still essentially the PS2 original and certain things haven't been changed or modernised. But that's fine. I didn't expect much more than the same game but with a visual bump going in so for so much of the game to be improved was quite impressive to me.

It's a really fun game and I definitely think for the most part effectively replaces the original, which is the best I can ask for from a remake.

A great remake of a PS2 cult classic, maintaining both the charm of the original while also bringing something new to the table in it's long awaited comeback to the current gen.

It was very fun revisiting a game I played quite a bit in my childhood and having the opportunity to actually complete it. The humour is some of the best in a video game (akin to Grand Theft Auto) with very serious themes hidden beneath the surface of seemingly harmless jokes. The plot isn't too much to look at, but it's a nice backdrop for a game with some interesting gameplay mechanics and sense of replayability.

I'd wager this is one of the best remakes to date and one of the best cult classic PS2 titles as well, up there with the likes of Spyro, Ratchet & Clank and Crash Bandicoot. An often overlooked classic that deserves recognition and now has it's opportunity to do so.