MGS4 microwave hallway wore people's thumbs to a nub, same could probably be said of the series other torture scenes

Sonic Blast Man on arcade!

mario party

Berzerk (1980)

I'm playing no more heroes 2 for the first time and the treadmill minigame has absolutely caused me pain.

im pretty sure the drakengard ost was intentionally designed to be headache enducing

Pathologic 2 stressed me to the point of making me feel physically ill.

Ring Fit and Mario Kart 8

melee?

yeah seconding melee, that dudes hand exploding after iirc multishining is pretty horrific

This list definitely requires some form of DDR game - some of those dancemats were lethal.

one could argue gachas can fit because of the financial damage and gambling problem exploitation they've done to some players