Snatcher, Policenauts, Shenmue, Street Fighter III: 3rd Strike, Deus Ex, Touhou 6: Embodiment of Scarlet Devil, Dragon Quest V, Castlevania: Rondo of Blood, Night Trap, Beyond Good & Evil, Another World, Conker's Bad Fur Day, Panzer Dragoon and Soul Reaver. And yup, definitely Mother 3.

Definitely Persona 5, original or Royal

Deus Ex Series and Panzer Dragoon Saga

We should just toss Duke Nukem on there, how many fans are there from the memes vs how many people that have actually played a Duke Nukem game. Same argument for Half-Life 1.

Persona 5 is a must on this list, a lot of "fans" watched it on youtube

One that people haven't mentioned yet and I feel aligns better with the original intention of the list: Spec Ops: The Line. Or maybe it doesn't fit because no one actually plays it after watching the 1 hour video essay?

And funnily enough, I went to look for video essays just after writing this comment, and I found out that the game has been removed from Steam and every other store by the developer, so now no one will actually play it!

Persona 5 and Metal Gear Rising are really obvious picks for this list. The entire Yakuza series too to an extent probably

Honestly Hollow Knight is the first game I thought of when I heard this concept.

Where's Touhou? Literally the definitive example of this.

So many comments, I can't possibly reply to each but I've added the stuff I'm knowledgable about enough to add. Will add a follow-up comment soon maybe giving more reasoning.

I feel like Vanquish is on here for sure

the game dev/gaming twitter list

I think Splatoon series might fit. I know many people who never ever played any of the games, but know every lore detail XD